Prof. Sigal Zilcha-Mano
Head of the Psychotherapy Research Lab
Research areas:
- Large-scale multimodal capability: Integration of physiological, behavioral, acoustic, motion, facial expression, and wearable data across thousands of clinically assessed psychotherapy sessions.
- Clinically grounded and innovative personalization: Gold-standard calibration using HDRS and other structured clinical interviews, with innovative separation of trait-like differences and state-like processes.
- Proven AI readiness: Decades of validated biomarkers, over 1,000 observations of clinical- and smartphone-based data, and machine-learning models trained on real-world clinical populations.
- Strong industry & translational experience: Extensive experience translating academic innovation into proof-of-concept systems aligned with real-world deployment constraints.
Full Professor at the Department of Psychology & Data Science Centre, and the Head of the Psychotherapy Research Lab, University of Haifa.
Prof. Sigal Zilcha-Mano is a worldwide recognized leader in personalized detection and intervention for depression. Her pioneering research leverages the separation of trait-like and state-like processes to achieve precise personalization in mental health treatment. She is a Member of the Israel National Academy of Sciences and a Fellow of the American Psychological Association (APA).
The Psychotherapy Research Lab consists of over 65 researchers, postdocs, and PhD students. The lab develops clinically validated, AI-driven technologies for personalized mental health. By integrating multimodal data from wearables, smartphones, and clinical assessments, the lab models individual-specific trajectories to enable early detection and scalable digital health solutions.
Selected Awards & Recognitions
- Member, National Academy of Sciences (Israel), 2025.
Mid-Career Research Excellence Award, 2024, University of Haifa.
Early Career Award 2020, International Society for the Exploration of Psychotherapy Integration (SEPI).
Fellow Status 2019, American Psychological Association (APA).
Early Career Award 2019, APA Division 29 (Psychotherapy).
Editorial Roles: Associate Editor and Editorial Board member for American Psychologist and Journal of Consulting and Clinical Psychology.
Major Research Grants
Prof. Zilcha-Mano has secured over €6.3M in competitive funding from prestigious bodies:
- ERC Consolidator Grant (2024–2029): Individual-specific understanding of how synchrony becomes curative (€2.12M).
- ERC Proof of Concept (2025): Proactive Mental Health through Multimodal Smartphone App (€150K).
- Israel Science Foundation (ISF): Mechanisms of change in psychotherapy research for depression.
- United States-Israel Binational Science Foundation (BSF): Manipulating visit frequency to understand placebo effects in depression (€200,000).
- National Institute for Psychobiology (2023–2025) – Neural mechanisms of expectancy effect in psychotherapy for MDD (€33,500)
Prof. Sigal Zilcha-Mano
Head of the Psychotherapy Research Lab
Research areas:
- Large-scale multimodal capability: Integration of physiological, behavioral, acoustic, motion, facial expression, and wearable data across thousands of clinically assessed psychotherapy sessions.
- Clinically grounded and innovative personalization: Gold-standard calibration using HDRS and other structured clinical interviews, with innovative separation of trait-like differences and state-like processes.
- Proven AI readiness: Decades of validated biomarkers, over 1,000 observations of clinical- and smartphone-based data, and machine-learning models trained on real-world clinical populations.
- Strong industry & translational experience: Extensive experience translating academic innovation into proof-of-concept systems aligned with real-world deployment constraints.
Full Professor at the Department of Psychology & Data Science Centre, and the Head of the Psychotherapy Research Lab, University of Haifa.
Prof. Sigal Zilcha-Mano is a worldwide recognized leader in personalized detection and intervention for depression. Her pioneering research leverages the separation of trait-like and state-like processes to achieve precise personalization in mental health treatment. She is a Member of the Israel National Academy of Sciences and a Fellow of the American Psychological Association (APA).
The Psychotherapy Research Lab consists of over 65 researchers, postdocs, and PhD students. The lab develops clinically validated, AI-driven technologies for personalized mental health. By integrating multimodal data from wearables, smartphones, and clinical assessments, the lab models individual-specific trajectories to enable early detection and scalable digital health solutions.
Selected Awards & Recognitions
- Member, National Academy of Sciences (Israel), 2025.
Mid-Career Research Excellence Award, 2024, University of Haifa.
Early Career Award 2020, International Society for the Exploration of Psychotherapy Integration (SEPI).
Fellow Status 2019, American Psychological Association (APA).
Early Career Award 2019, APA Division 29 (Psychotherapy).
Editorial Roles: Associate Editor and Editorial Board member for American Psychologist and Journal of Consulting and Clinical Psychology.
Major Research Grants
Prof. Zilcha-Mano has secured over €6.3M in competitive funding from prestigious bodies:
- ERC Consolidator Grant (2024–2029): Individual-specific understanding of how synchrony becomes curative (€2.12M).
- ERC Proof of Concept (2025): Proactive Mental Health through Multimodal Smartphone App (€150K).
- Israel Science Foundation (ISF): Mechanisms of change in psychotherapy research for depression.
- United States-Israel Binational Science Foundation (BSF): Manipulating visit frequency to understand placebo effects in depression (€200,000).
- National Institute for Psychobiology (2023–2025) – Neural mechanisms of expectancy effect in psychotherapy for MDD (€33,500)