{"id":2896,"date":"2026-01-14T13:14:27","date_gmt":"2026-01-14T13:14:27","guid":{"rendered":"https:\/\/carmel-ltd.haifa.ac.il\/?post_type=researchers&#038;p=2896"},"modified":"2026-02-04T15:02:15","modified_gmt":"2026-02-04T15:02:15","slug":"prof-sarit-larisch","status":"publish","type":"researchers","link":"https:\/\/carmel-ltd.haifa.ac.il\/?researchers=prof-sarit-larisch","title":{"rendered":"Prof. Sarit Larisch"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2896\" class=\"elementor elementor-2896\" data-elementor-post-type=\"researchers\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a2b3a7c e-flex e-con-boxed e-con e-parent\" data-id=\"a2b3a7c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c3f84e elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"9c3f84e\" data-element_type=\"widget\" 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data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_transform_rotateZ_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_rotateZ_effect_tablet&quot;:{&quot;unit&quot;:&quot;deg&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_rotateZ_effect_mobile&quot;:{&quot;unit&quot;:&quot;deg&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9074181 elementor-widget elementor-widget-image\" data-id=\"9074181\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"796\" src=\"https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-1024x796.jpg\" class=\"attachment-large size-large wp-image-2897\" alt=\"\" srcset=\"https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-1024x796.jpg 1024w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-300x233.jpg 300w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-768x597.jpg 768w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-1536x1194.jpg 1536w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-2048x1591.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5dcc14a e-con-full e-flex e-con e-child\" data-id=\"5dcc14a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4c20d10 elementor-widget elementor-widget-heading\" data-id=\"4c20d10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Prof. Sarit Larisch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b83be35 elementor-widget elementor-widget-ucaddon_social_icons_glare_effect\" data-id=\"b83be35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_social_icons_glare_effect.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Social Icons Glare Effect -->\n\t\t<link id='font-awesome-css' href='https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-all.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='font-awesome-4-shim-css' href='https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-v4-shims.min.css' type='text\/css' rel='stylesheet' >\n\n<style>\/* widget: Social Icons Glare Effect *\/\n\n#uc_social_icons_glare_effect_elementor_b83be35 *{\n\n\tbox-sizing: border-box;\n}\n\n#uc_social_icons_glare_effect_elementor_b83be35{\n\tposition:relative;\n\twidth:100%;\n}\n\n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button {\n    box-shadow: 0 0 30px 0 rgba(0, 0, 0, 0.05);\n    display: inline-block;\n    opacity: 1;\n    overflow: hidden;\n    position: relative;\n    text-align: center;\n    transition: all 0.35s cubic-bezier(0.31, -0.105, 0.43, 1.59) 0s;\n    \n}\n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button::before {\n    content: \"\";\n    height: 100%;\n    left: 0%;\n    position: absolute;\n    top: 100%;\n    transition: all 0.35s;\n    width: 100%;\n}\n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button i {\n    transform: scale(0.8);\n    transition: all 0.35s cubic-bezier(0.31, -0.105, 0.43, 1.59) 0s;\n    vertical-align: middle;\n}\n\n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button:focus::before, \n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button:hover::before {\n    left: 0%;\n    top: 0%;\n}\n\n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button i {\n\tcolor:#FFFFFF;\n}\n\n#uc_social_icons_glare_effect_elementor_b83be35 .uc_social-button:hover i {\n\tcolor:#A1F8FD;\n}\n\n<\/style>\n\n<div class=\"uc_stylish_social_buttons\" id=\"uc_social_icons_glare_effect_elementor_b83be35\"> \n    <!--uc_container_holder--> \n    <div class=\"uc_social-buttons\">\n    \t<a href=\"http:\/\/larischlab.haifa.ac.il\" class=\"uc_social-button\"   target='_blank'><i class=\"fas fa-globe\"><\/i><\/a>\n<a href=\"https:\/\/www.linkedin.com\/in\/prof-sarit-larisch-183a16\/\" class=\"uc_social-button\"  ><i class=\"fab fa-linkedin\"><\/i><\/a>\n\n    <\/div>\n<\/div>\n<!-- end Social Icons Glare Effect -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e60bdb elementor-widget elementor-widget-heading\" data-id=\"2e60bdb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Head of Cell Death and Cancer Research Laboratory <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3e452 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"2a3e452\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"mailto:slarisch@univ.haifa.ac.il\" class=\"elementor-icon elementor-animation-grow\" tabindex=\"-1\" aria-label=\"slarisch@univ.haifa.ac.il\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"mailto:slarisch@univ.haifa.ac.il\" >\n\t\t\t\t\t\t\tslarisch@univ.haifa.ac.il\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ab929f elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"6ab929f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"mailto:saritlarisch@gmail.com\" class=\"elementor-icon elementor-animation-grow\" tabindex=\"-1\" aria-label=\"saritlarisch@gmail.com\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"mailto:saritlarisch@gmail.com\" >\n\t\t\t\t\t\t\tsaritlarisch@gmail.com\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5198942 elementor-widget elementor-widget-ucaddon_toggle_text_button\" data-id=\"5198942\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_toggle_text_button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Toggle Text Button -->\n<style>\/* widget: Toggle Text Button *\/\n\n#uc_toggle_text_button_elementor_5198942 .read_more{\n  text-decoration:none;\n  font-size:14px;\n  color:white;\n  transition:0.3s;\n  cursor: pointer;\n}\n\n<\/style>\n\n<div id=\"uc_toggle_text_button_elementor_5198942\" class=\"toggle_text_button\"> \n  \n  <div class=\"short_txt\"><\/div>   \n  <div class=\"long_txt\" style=\"display:none;\"><h3><span style=\"color: #a1f8fd;\">Research areas:<\/span><\/h3><ul><li><span style=\"text-decoration: underline;\"><strong>p53 regulation and cancer therapy<\/strong><\/span><br \/>We discovered that ARTS is a direct transcriptional target of p53 and uncovered a novel ARTS-XIAP-p53 regulatory axis controlling p53 stability through the ubiquitin\u2013proteasome system. This work identifies XIAP as a druggable E3 ligase for p53 and provides a new strategy to restore p53 activity with ARTS-mimetic compounds in cancers with impaired p53 regulation.<\/li><li><span style=\"text-decoration: underline;\"><strong>PROTAC-like small molecules targeting XIAP and Bcl-2<\/strong><\/span><br \/>We identified and developed small-molecule ARTS mimetics that function in a PROTAC-like manner to selectively bind and promote proteasomal degradation of XIAP and Bcl-2. These compounds directly bind to XIAP and Bcl-2 and selectively induce apoptosis in cancer cells while sparing normal cells, including in a mouse neuroblastoma model. This establishes a strong foundation for first-in-class apoptosis-based therapeutics.<\/li><li><span style=\"text-decoration: underline;\"><strong>Preventing breast cancer and intercepting early disease<\/strong><\/span><br \/>We have discovered that pharmacological activation of the ARTS-XIAP pathway <u>reverses<\/u> early premalignant changes in breast patient-derived breast organoids back to a normal epithelial state, while selectively killing malignant breast cancer cells and sparing normal epithelium. This approach defines a new strategy for early cancer interception that is particularly relevant for high-risk populations, such as BRCA1\/2 mutation carriers.<\/li><li><span style=\"text-decoration: underline;\"><strong>Inflammatory bowel disease and XIAP modulation<\/strong><\/span><br \/>We identified a critical role for ARTS-XIAP dysregulation in excessive epithelial cell death and inflammation in IBD (Inflammatory Bowel Disease models). Our work opens a new therapeutic avenue aimed at restoring normal XIAP function to reduce tissue damage and inflammation, with the potential to benefit millions of IBD patients worldwide.<\/li><\/ul><\/div>  \n  \n  <div style=\"text-align:inherit;\">  \n    <span class=\"read_more\">\n      <span class=\"btn_txt_before_click\"><span  class=\"uc_style_toggle_text_button_elementor_button_text\" style=\"color:#1F3343;\">Research areas >><\/span><\/span>\n      <span class=\"btn_txt_after_click\" style=\"display:none;\"><span  class=\"uc_style_toggle_text_button_elementor_button_text_close\" style=\"color:#1F3343;\">Show Less<\/span><\/span>\n    <\/span>  \n  <\/div>  \n<\/div>\n<!-- end Toggle Text Button -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8d2390 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b8d2390\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd668c4 elementor-widget elementor-widget-text-editor\" data-id=\"cd668c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Sarit Larisch is Professor and Head of Cell Death and Cancer Research Laboratory at the University of Haifa, and past chair of the Departments of Biology and Medical Sciences. She received her Ph.D. from the Hebrew University-Hadassah Medical School and conducted her post-doctoral studies at the National Cancer Institute in Bethesda, USA. She discovered the ARTS protein and devoted her career to understanding its role in cancer as basis for developing novel anti-cancer therapies. She received many awards, including the Wolfson Trust Award and the Johnson &amp; Johnson Focused Funding Award. Prof. Larisch holds eleven patents and patent applications.<\/p><p>The lab investigates how apoptotic signaling can be harnessed for disease prevention and therapy. A major contribution of my work is the discovery of ARTS, a tumor suppressor protein whose expression is frequently lost in human cancers. Genetic studies in ARTS-deficient mice demonstrated spontaneous tumor development, establishing ARTS as a physiological tumor suppressor. ARTS is a direct antagonist of XIAP. We have identified small molecules that show high affinity for the unique binding site of ARTS in Bir3\/XIAP and promote efficient killing of a wide variety of cancer cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e29033 e-flex e-con-boxed e-con e-parent\" data-id=\"5e29033\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ec9be7f elementor-hidden-desktop elementor-hidden-tablet e-con-full e-flex e-con e-child\" data-id=\"ec9be7f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4f2d887 e-con-full e-transform e-flex e-con e-child\" data-id=\"4f2d887\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_transform_rotateZ_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_rotateZ_effect_tablet&quot;:{&quot;unit&quot;:&quot;deg&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_rotateZ_effect_mobile&quot;:{&quot;unit&quot;:&quot;deg&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9f1e3e7 elementor-widget elementor-widget-image\" data-id=\"9f1e3e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2048\" height=\"1591\" src=\"https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-2048x1591.jpg\" class=\"attachment-2048x2048 size-2048x2048 wp-image-2897\" alt=\"\" srcset=\"https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-2048x1591.jpg 2048w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-300x233.jpg 300w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-1024x796.jpg 1024w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-768x597.jpg 768w, https:\/\/carmel-ltd.haifa.ac.il\/wp-content\/uploads\/2026\/01\/Sarit-Larish-1536x1194.jpg 1536w\" sizes=\"(max-width: 2048px) 100vw, 2048px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ee7a927 e-con-full e-flex e-con e-child\" data-id=\"ee7a927\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aeb5e9b elementor-widget elementor-widget-heading\" data-id=\"aeb5e9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Prof. Sarit Larisch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4117740 elementor-widget elementor-widget-heading\" data-id=\"4117740\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Head of Cell Death and Cancer Research Laboratory<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ada090 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"6ada090\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"mailto:saritlarisch@gmail.com\" class=\"elementor-icon elementor-animation-grow\" tabindex=\"-1\" aria-label=\"saritlarisch@gmail.com\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"mailto:saritlarisch@gmail.com\" 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48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"mailto:slarisch@univ.haifa.ac.il\" >\n\t\t\t\t\t\t\tslarisch@univ.haifa.ac.il\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1406587 elementor-widget elementor-widget-ucaddon_social_icons_glare_effect\" data-id=\"1406587\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_social_icons_glare_effect.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Social Icons Glare Effect -->\n\n<style>\/* widget: Social Icons Glare Effect *\/\n\n#uc_social_icons_glare_effect_elementor_1406587 *{\n\n\tbox-sizing: border-box;\n}\n\n#uc_social_icons_glare_effect_elementor_1406587{\n\tposition:relative;\n\twidth:100%;\n}\n\n#uc_social_icons_glare_effect_elementor_1406587 .uc_social-button {\n    box-shadow: 0 0 30px 0 rgba(0, 0, 0, 0.05);\n    display: inline-block;\n    opacity: 1;\n    overflow: hidden;\n    position: relative;\n    text-align: center;\n    transition: all 0.35s cubic-bezier(0.31, -0.105, 0.43, 1.59) 0s;\n    \n}\n#uc_social_icons_glare_effect_elementor_1406587 .uc_social-button::before {\n    content: \"\";\n    height: 100%;\n    left: 0%;\n    position: absolute;\n    top: 100%;\n    transition: all 0.35s;\n    width: 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class=\"uc_social-button\"   target='_blank'><i class=\"fab fa-linkedin\"><\/i><\/a>\n\n    <\/div>\n<\/div>\n<!-- end Social Icons Glare Effect -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2a9317 elementor-widget elementor-widget-ucaddon_toggle_text_button\" data-id=\"c2a9317\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_toggle_text_button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Toggle Text Button -->\n<style>\/* widget: Toggle Text Button *\/\n\n#uc_toggle_text_button_elementor_c2a9317 .read_more{\n  text-decoration:none;\n  font-size:14px;\n  color:white;\n  transition:0.3s;\n  cursor: pointer;\n}\n\n<\/style>\n\n<div id=\"uc_toggle_text_button_elementor_c2a9317\" class=\"toggle_text_button\"> \n  \n  <div class=\"short_txt\"><\/div>   \n  <div class=\"long_txt\" style=\"display:none;\"><h3><span style=\"color: #a1f8fd;\">Research areas:<\/span><\/h3><ul><li><span style=\"text-decoration: underline;\"><strong>p53 regulation and cancer therapy<\/strong><\/span><br \/>We discovered that ARTS is a direct transcriptional target of p53 and uncovered a novel ARTS-XIAP-p53 regulatory axis controlling p53 stability through the ubiquitin\u2013proteasome system. This work identifies XIAP as a druggable E3 ligase for p53 and provides a new strategy to restore p53 activity with ARTS-mimetic compounds in cancers with impaired p53 regulation.<\/li><li><span style=\"text-decoration: underline;\"><strong>PROTAC-like small molecules targeting XIAP and Bcl-2<\/strong><\/span><br \/>We identified and developed small-molecule ARTS mimetics that function in a PROTAC-like manner to selectively bind and promote proteasomal degradation of XIAP and Bcl-2. These compounds directly bind to XIAP and Bcl-2 and selectively induce apoptosis in cancer cells while sparing normal cells, including in a mouse neuroblastoma model. This establishes a strong foundation for first-in-class apoptosis-based therapeutics.<\/li><li><span style=\"text-decoration: underline;\"><strong>Preventing breast cancer and intercepting early disease<\/strong><\/span><br \/>We have discovered that pharmacological activation of the ARTS-XIAP pathway <u>reverses<\/u> early premalignant changes in breast patient-derived breast organoids back to a normal epithelial state, while selectively killing malignant breast cancer cells and sparing normal epithelium. This approach defines a new strategy for early cancer interception that is particularly relevant for high-risk populations, such as BRCA1\/2 mutation carriers.<\/li><li><span style=\"text-decoration: underline;\"><strong>Inflammatory bowel disease and XIAP modulation<\/strong><\/span><br \/>We identified a critical role for ARTS-XIAP dysregulation in excessive epithelial cell death and inflammation in IBD (Inflammatory Bowel Disease models). Our work opens a new therapeutic avenue aimed at restoring normal XIAP function to reduce tissue damage and inflammation, with the potential to benefit millions of IBD patients worldwide.<\/li><\/ul><\/div>  \n  \n  <div style=\"text-align:inherit;\">  \n    <span class=\"read_more\">\n      <span class=\"btn_txt_before_click\"><span  class=\"uc_style_toggle_text_button_elementor_button_text\" style=\"color:#1F3343;\">Research areas >><\/span><\/span>\n      <span class=\"btn_txt_after_click\" style=\"display:none;\"><span  class=\"uc_style_toggle_text_button_elementor_button_text_close\" style=\"color:#1F3343;\">Show Less<\/span><\/span>\n    <\/span>  \n  <\/div>  \n<\/div>\n<!-- end Toggle Text Button -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0dc953b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0dc953b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8693ee elementor-widget elementor-widget-text-editor\" data-id=\"b8693ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Sarit Larisch is Professor and Head of Cell Death and Cancer Research Laboratory at the University of Haifa, and past chair of the Departments of Biology and Medical Sciences. She received her Ph.D. from the Hebrew University-Hadassah Medical School and conducted her post-doctoral studies at the National Cancer Institute in Bethesda, USA. She discovered the ARTS protein and devoted her career to understanding its role in cancer as basis for developing novel anti-cancer therapies. She received many awards, including the Wolfson Trust Award and the Johnson &amp; Johnson Focused Funding Award. Prof. Larisch holds eleven patents and patent applications.<\/p><p>The lab investigates how apoptotic signaling can be harnessed for disease prevention and therapy. A major contribution of my work is the discovery of ARTS, a tumor suppressor protein whose expression is frequently lost in human cancers. Genetic studies in ARTS-deficient mice demonstrated spontaneous tumor development, establishing ARTS as a physiological tumor suppressor. ARTS is a direct antagonist of XIAP. We have identified small molecules that show high affinity for the unique binding site of ARTS in Bir3\/XIAP and promote efficient killing of a wide variety of cancer cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6eebf34 e-flex e-con-boxed e-con e-parent\" data-id=\"6eebf34\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-253015f elementor-widget elementor-widget-spacer\" data-id=\"253015f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Areas:<br \/>\nArtificial Intelligence<br \/>\n Breast Cancer Prevention and Early Interception<br \/>\nDisease Research and Prevention Strategies<br \/>\nMedical Applications<br \/>\nProteins<\/p>\n","protected":false},"featured_media":2897,"template":"elementor_header_footer","tags":[15,16,17,18,19,10],"class_list":["post-2896","researchers","type-researchers","status-publish","has-post-thumbnail","hentry","tag-breast-cancer-prevention-and-early-interception","tag-disease-research-and-prevention-strategies","tag-drug-development","tag-medical-applications","tag-proteins","tag-artificial-inteligence","entry","has-media"],"acf":[],"_links":{"self":[{"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/researchers\/2896","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/researchers"}],"about":[{"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/types\/researchers"}],"version-history":[{"count":17,"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/researchers\/2896\/revisions"}],"predecessor-version":[{"id":5053,"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/researchers\/2896\/revisions\/5053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/media\/2897"}],"wp:attachment":[{"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2896"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/carmel-ltd.haifa.ac.il\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}